Former Scholar Featured in Nature

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Paul Tesar – a former NIH-Oxford-Cambridge Scholar was featured in Nature discussing how having two mentors can lead to breakthrough research.

The article below is posted online with the permission of Nature Publishing Group. The original article can be found here.

Turning point: Paul Tesar

By Virginia Gewin

Nature 522, 381 (2015) doi:10.1038/nj7556-381a

Published online 17 June 2015

This article was originaly published in the journal Nature

Paul Tesar discovered a new type of mouse stem cell in 2007 and published his discovery in Nature as a graduate student at the University of Oxford, UK. The paper launched him rapidly to a professorship at Case Western Reserve University (CWRU) in Cleveland, Ohio, where he continues to drive the field forward.

How did your graduate experience shape your career pursuits?

I was part of a joint programme — the US National Institutes of Health (NIH) Oxford–Cambridge Scholars Program — and split my time working with NIH human-stem-cell biologist Ron McKay and Oxford mouse embryologist Richard Gardner. I had a great deal of independence from day one. My first publication was a solo-authored paper in theProceedings of the National Academies of Science (P. Tesar Proc. Natl Acad. Sci. USA 102, 8239–8244; 2005) — a feat almost unheard of today.

How crucial was the fellowship to your stem-cell discovery?

I didn’t set out to discover another pluripotent state. But my ‘eureka’ moment came when I derived mouse embryonic stem cells with similar characteristics to human ones, including the ability to differentiate into all other tissue types, known as pluripotency (P. Tesar et al. Nature 448, 196–199; 2007). It took a while to prove that there was more than one pluripotent state, but that paper triggered a frame shift in the field. Epiblast stem cells would have been discovered anyway, but drawing the NIH and Oxford research together put that revelation in our hands. So strongly do I feel that dual mentoring arrangements are fruitful, that I encourage my students to find mentors with different skill sets.

What happened after the epiblast publication?

I was looking for my next position and wanted to maintain my level of independence. I also wanted to go back to Cleveland someday, and the CWRU — where I earned my bachelor’s in biology — encouraged me to return. After I explained my goals, they created a one-off position that gave me a few years of funding and my own independent lab straight away. Things went better than I could have hoped. I hired good people and published some strong papers. The next year, at 28 years old, I applied for a faculty position. It was a whirlwind experience.

How did you maintain momentum?

In 2010, I was named a New York Stem Cell Foundation Robertson Investigator, which gave me US$1.5 million in innovation funding. That was enough to grow my lab from 3 to 12 members and to drive our research into unexplored areas. It was such a new field that I was able to rapidly address some major questions.

Is stem-cell biology entering a ‘golden age’?

People have expected much from this promising field; it is time to deliver. Stem-cell transplantations are feasible and will continue to advance — and we are learning how to control stem-cell populations to perform specific functions. For example, recently, we screened for drugs that can stimulate the generation of a brain-cell type that is typically lost in diseases such as multiple sclerosis. There has been a huge uptick in the number of stem-cell-based trials, and the results of those will guide the future.

Do you do much work at the bench?

I would love to, but I spend most of my time writing grant proposals and renewals, progress reports and paper reviews. Unfortunately, I am really there only during the holidays after I have sent everyone home. They trust me enough to grow cells.

What is the best career advice that you have given or received?

They are one and the same: maintain work–life balance. The 24–7 culture of always answering e-mail and working through the night is counterproductive. I tell my students that working 12–15 hours a day does not equal a Nature paper; being smart about which experiments you pick will get you high-profile publications. When people are happy and stress-free, they can be creative and explore new areas.

Lasker Foundation and Alliance to Host Lasker Lessons in Leadership on August 4, 2015

Lasker Foundation and Alliance to Host Lasker Lessons in Leadership on August 4, 2015

The second Lasker Lessons in Leadership lecture, with keynote speaker Dr. Dan Littman and discussion panelists Dr. Alan Sher, Dr. Beverly Purnell, and Dr. Enrique Schisterman will take place on August 4th on the NIH main campus in Bethesda, Maryland. This lecture and panel discussion will focus upon providing experienced advice on how successful leaders communicate and publish their science.  Some of the questions to be covered will be knowing when to publish and when a story is complete, common mistakes made in writing papers, and why papers are most often rejected.  Writing is hard – come learn how to become a better writer and communicator of your science.

A series of one-day lectures, the Lasker Lessons in Leadership was developed by the Albert and Mary Lasker Foundation in collaboration with the International Biomedical Research Alliance and the NIH Oxford-Cambridge Scholars Program to help postgraduate medical research students navigate their careers and develop critical leadership skills.  The Scholars Program has revolutionized the way in which the most talented students receive accelerated training on collaborative projects performed between laboratories in the US and EU.  Lasker Foundation President Claire Pomeroy, MD, MBA, said “The next generation of physicians and scientists is key to ensuring that biomedical research flourishes into the future.  In addition to scientific knowledge, these young researchers must have the leadership skills necessary to guide innovation and scientific discovery.  The Albert and Mary Lasker Foundation is pleased to partner to create the Lasker Lessons in Leadership program to address this need.”

WIRB-Copernicus Group (WCG), the world’s largest provider of regulatory and ethical review services and software to support clinical research, and Certara, the global biosimulation technology-enabled drug development consultancy, are co-sponsoring several of the lectures.

Please email rb@biomedalliance.org for additional details.

Follow this link http://www.laskerfoundation.org/programs/leadership.htm to read about the Lasker Lessons in Leadership, with keynote speaker Dr. Ralph Snyderman, held in May of 2015..

2015 Annual Research Colloquium in Cambridge

2015 Annual Research Colloquium in Cambridge

The NIH Oxford-Cambridge Scholars Program will hold the 2015 Annual Research Colloquium June 22-24th, 2015. This year the Colloquium will be hosted by the University of Cambridge at Downing College. In addition to a number of student presentations showcasing their extraordinary work, a stellar line-up of talks and workshops will be delivered by senior and leading academics including Publishing Science, Molecular Biology, Genetics, Big Data, Working in Industry, Clinical and Translational Immunology, and Protein Biosynthesis. Sponsors of this year’s Colloquium include WIRB-Copernicus Group (WCG), the world’s largest provider of regulatory and ethical review services and software to support clinical research, and Certara®, the global biosimulation technology-enabled drug development consultancy, and the International Biomedical Research Alliance.

Full agenda can be viewed here: NIH OxCam Cambridge Colloquium 2015 Schedule

NIH OxCam Scholar Advances Cancer Detection using Nanodiamonds

NIH OxCam Scholar Advances Cancer Detection using Nanodiamonds

NIH Oxford-Cambridge Program Scholar Alumna, Dr. Ambika Bumb’s biotech company, Bikanta, has developed nanodiamond-based technology that assists in the early detection of cancer.  Through the use of fluorescent nanodiamonds, medical imaging is enhanced, allowing cancer to be detected in deep tissue.  Bikanta’s nanodiamonds are superior optical probes that emit a bright and stable signal, that is customizable (to target specific diseases) and nontoxic.

Ambika graduated from Georgia Tech and obtained her doctorate from Oxford while on the prestigious Marshall Scholarship. She completed two post-doctoral fellowships at the National Cancer Institute and National Heart, Lung and Blood Institute where she developed Bikanta’s nanodiamond-based technologies.  She has received numerous scholarships and awards for excellence in engineering and was profiled in 2011 in Nature as a successful young scientist on the fast-track. Her work in the areas of nanomedicine and diagnostics has led to multiple patents and many publications.

You can read more about how Ambika founded Bikanta here:

http://www.femalefounderstories.com/ambika-bumb.html

You can read more about Bikanta’s nanodiamond technology here:

http://techcrunch.com/2014/08/07/bikantas-tiny-diamonds-find-cancer-before-it-spreads/

NIH Oxford-Cambridge Scholar wins MacArthur Fellowship

NIH Oxford-Cambridge Scholar wins MacArthur Fellowship

The International Biomedical Research Alliance is proud to congratulate a remarkable NIH Oxford-Cambridge Scholars Program graduate, Danielle Bassett (nee Perry), on her recent acceptance to the MacArthur Fellows Program.  The MacArthur Fellows Program awards unrestricted fellowships to talented individuals who have shown extraordinary originality and dedication in their creative pursuits and a marked capacity for self-direction. The MacArthur Fellows Program is intended to encourage people of outstanding talent to pursue their own creative, intellectual, and professional inclinations. In keeping with this purpose, the Foundation’s “no strings attached” award is made directly to individuals rather than through institutions.  Each fellowship comes with a stipend of $625,000 to the recipient, paid out over five years.  Typically 20 to 30 Fellows are selected each year. In 1981 when the first class of fellows was named, the media coined the nickname “Genius Grant” to describe the fellowship.

Home-schooled from age 4 through high school, Dani received her B.S. (2004) from Pennsylvania State University and was a member of Penn State’s Schreyer Honors College. She received a Certificate of Postgraduate Study (2005) from the University of Cambridge through a Winston Churchill Scholarship and Ph.D. (2009) from the University of Cambridge through the Alliance supported NIH Oxford-Cambridge Scholars Program where her research in Meyer-Lindenberg’s NIMH lab focused on the human brain, particularly involving alterations in neural circuitry underlying psychiatric disease.  At Cambridge, her mentors were Professor Thomas Duke (now deceased) in Physics and Professor Edward Bullmore in Experimental Psychology. She was a postdoctoral associate (2009–2011) and a Sage Junior Research Fellow (2011–2013) at the University of California, Santa Barbara, before joining the faculty of the University of Pennsylvania, where she is currently the Skirkanich Assistant Professor of Innovation in the Departments of Bioengineering and Electrical & Systems Engineering.  She is considered is one of the foremost investigators of neural networks designed to understand how humans think.

It is important to note that Dani completed her Ph.D. in the NIH Oxford-Cambridge Scholars Program in just under the average time to completion rate of 4.0 years. When asked about Dani and the NIH Oxford-Cambridge Scholars Program, mentor Dr. Ed Bullmore noted that “The quality of the students in the NIH Oxford-Cambridge Scholars Program is truly outstanding. These are some of the smartest young people at the start of their careers in science and it is a privilege to work with them. But even by the exalted standards of this program, Dani Bassett was exceptional. She was remarkably productive, scientifically innovative and efficiently focused. She wrote some terrific papers herself in Cambridge and she was also a generous and effective collaborator and guide to other students in the lab. I was very proud but not very surprised when she won the MacArthur award. I think the NIH Oxford-Cambridge Scholars Program deserves a lot of credit for creating a unique opportunity for highly talented people like Dani to make a flying start to their lives in science and medicine.”

Dr. Ralph Synderman to speak at Inaugural Lasker Lessons in Leadership

Dr. Ralph Synderman to speak at Inaugural Lasker Lessons in Leadership

Dr. Ralph Snyderman, Chancellor Emeritus and James B. Duke Professor of Medicine at Duke University will be the inaugural speaker for the Lasker Lessons in Leadership to be held on the campus of the NIH on May 19, 2015.  Dr. Snyderman’s talk entitled “From Brooklyn to Lab Bench to Board Room: Lessons Learned” will seek to provide sage advice to researchers at the beginning of their careers including the NIH-Lasker Research Scholars and NIH Oxford-Cambridge Scholars.  More details to follow. For additional information regarding this event please email Randi Balletta at rb@biomedalliance.org.